Fluorinated Building Blocks in Drug Design
Published 2025-05-12
Fluorine substitution changes metabolic stability, acidity and binding.
Introducing fluorine into a drug candidate modifies metabolic stability, membrane permeability and the acidity of nearby functional groups. Fluorinated building blocks such as fluoroarenes and trifluoromethyl aromatics let medicinal chemists install these effects early in the route rather than late-stage fluorination.